Antigenic Variation of Clade 2.1 H5N1 Virus Is Determined by a Few Amino Acid Substitutions Immediately Adjacent to the Receptor Binding Site

Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are genetically highly variable and have diversified into multiple phylogenetic clades over the past decade. Antigenic drift is a well-studied phenomenon for seasonal human influenza viruses, but much less is known about the antige...

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Auteurs principaux: Koel, Björn F., van der Vliet, Stefan, Burke, David F., Bestebroer, Theo M., Bharoto, Eny E., Yasa, I. Wayan W., Herliana, Inna, Laksono, Brigitta M., Xu, Kemin, Skepner, Eugene, Russell, Colin A., Rimmelzwaan, Guus F., Perez, Daniel R., Osterhaus, Albert D. M. E., Smith, Derek J., Prajitno, Teguh Y., Fouchier, Ron A. M.
Format: Artigo
Langue:Inglês
Publié: American Society of Microbiology 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056550/
https://ncbi.nlm.nih.gov/pubmed/24917596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01070-14
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