Antigenic Variation of Clade 2.1 H5N1 Virus Is Determined by a Few Amino Acid Substitutions Immediately Adjacent to the Receptor Binding Site

Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are genetically highly variable and have diversified into multiple phylogenetic clades over the past decade. Antigenic drift is a well-studied phenomenon for seasonal human influenza viruses, but much less is known about the antige...

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Autores principales: Koel, Björn F., van der Vliet, Stefan, Burke, David F., Bestebroer, Theo M., Bharoto, Eny E., Yasa, I. Wayan W., Herliana, Inna, Laksono, Brigitta M., Xu, Kemin, Skepner, Eugene, Russell, Colin A., Rimmelzwaan, Guus F., Perez, Daniel R., Osterhaus, Albert D. M. E., Smith, Derek J., Prajitno, Teguh Y., Fouchier, Ron A. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Microbiology 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056550/
https://ncbi.nlm.nih.gov/pubmed/24917596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01070-14
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