DJ-1 Cleavage by Matrix Metalloproteinase 3 Mediates Oxidative Stress-Induced Dopaminergic Cell Death

Oxidative stress is commonly implicated in aging and neurodegenerative conditions such as Parkinson's disease (PD). Mutations in DJ-1 are associated with autosomal recessive early-onset PD. We investigated whether DJ-1 can be degraded in oxidative-stressed dopaminergic neuronal cells, leading t...

Full description

Saved in:
Bibliographic Details
Main Authors: Choi, Dong-Hee, Hwang, Onyou, Lee, Kyoung-Hee, Lee, Jongmin, Beal, M. Flint, Kim, Yoon-Seong
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2011
Subjects:
Original Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056461/
https://ncbi.nlm.nih.gov/pubmed/20969476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2009.3059
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items