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DJ-1 Cleavage by Matrix Metalloproteinase 3 Mediates Oxidative Stress-Induced Dopaminergic Cell Death

Oxidative stress is commonly implicated in aging and neurodegenerative conditions such as Parkinson's disease (PD). Mutations in DJ-1 are associated with autosomal recessive early-onset PD. We investigated whether DJ-1 can be degraded in oxidative-stressed dopaminergic neuronal cells, leading t...

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Detalhes bibliográficos
Main Authors: Choi, Dong-Hee, Hwang, Onyou, Lee, Kyoung-Hee, Lee, Jongmin, Beal, M. Flint, Kim, Yoon-Seong
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056461/
https://ncbi.nlm.nih.gov/pubmed/20969476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2009.3059
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