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A Role for Retrotransposon LINE-1 in Fetal Oocyte Attrition in Mice

Fetal oocyte attrition (FOA) is a conserved but poorly understood process of elimination of over two-thirds of meiotic prophase I (MPI) oocytes before birth. We now implicate retrotransposons LINE-1 (L1), activated during epigenetic reprogramming of the embryonic germline, in FOA in mice. We show th...

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Bibliografiske detaljer
Main Authors: Malki, Safia, van der Heijden, Godfried W., O'Donnell, Kathryn A., Martin, Sandra L., Bortvin, Alex
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056315/
https://ncbi.nlm.nih.gov/pubmed/24882376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.04.027
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