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CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene

Mutation in the Gjb1 gene, coding for a connexin (Cx32), is associated with an inherited peripheral neuropathic disorder (X-linked Charcot-Marie-Tooth, CMTX). Our previous work reported that transgenic animals expressing a human Gjb1 transgene present polyploidy and abnormal over-duplication of the...

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Detalhes bibliográficos
Main Authors: Mones, Saleh, Bordignon, Benoit, Peiretti, Franck, Landrier, Jean F., Gess, Burkhardt, Bourguignon, Jean J., Bihel, Frédéric, Fontés, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056282/
https://ncbi.nlm.nih.gov/pubmed/24982612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2014.00151
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