Septic serum induces glucocorticoid resistance and modifies the expression of glucocorticoid isoforms receptors: a prospective cohort study and in vitro experimental assay

BACKGROUND: A protective role for glucocorticoid therapy in animal models of sepsis was shown many decades ago. In human sepsis, there is new interest in glucocorticoid therapy at a physiological dose after reports of improved response to vasopressor drugs and decreased mortality in a selected group...

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Hlavní autoři: Guerrero, Julia, Gatica, Héctor A, Rodríguez, Margarita, Estay, Roberto, Goecke, Irmgadt Annelise
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056039/
https://ncbi.nlm.nih.gov/pubmed/23759144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc12774
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