Biogenesis of Influenza A Virus Hemagglutinin Cross-Protective Stem Epitopes

Antigenic variation in the globular domain of influenza A virus (IAV) hemagglutinin (HA) precludes effective immunity to this major human pathogen. Although the HA stem is highly conserved between influenza virus strains, HA stem-reactive antibodies (StRAbs) were long considered biologically inert....

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Main Authors: Magadán, Javier G., Altman, Meghan O., Ince, William L., Hickman, Heather D., Stevens, James, Chevalier, Aaron, Baker, David, Wilson, Patrick C., Ahmed, Rafi, Bennink, Jack R., Yewdell, Jonathan W.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055778/
https://ncbi.nlm.nih.gov/pubmed/24945804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004204
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