Protective Efficacy of Passive Immunization with Monoclonal Antibodies in Animal Models of H5N1 Highly Pathogenic Avian Influenza Virus Infection

Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype often cause severe pneumonia and multiple organ failure in humans, with reported case fatality rates of more than 60%. To develop a clinical antibody therapy, we generated a human-mouse chimeric monoclonal antibody (MAb) ch61 that...

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Detalhes bibliográficos
Main Authors: Itoh, Yasushi, Yoshida, Reiko, Shichinohe, Shintaro, Higuchi, Megumi, Ishigaki, Hirohito, Nakayama, Misako, Pham, Van Loi, Ishida, Hideaki, Kitano, Mitsutaka, Arikata, Masahiko, Kitagawa, Naoko, Mitsuishi, Yachiyo, Ogasawara, Kazumasa, Tsuchiya, Hideaki, Hiono, Takahiro, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi, Ito, Mutsumi, Quynh Mai, Le, Kawaoka, Yoshihiro, Miyamoto, Hiroko, Ishijima, Mari, Igarashi, Manabu, Suzuki, Yasuhiko, Takada, Ayato
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055766/
https://ncbi.nlm.nih.gov/pubmed/24945244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004192
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