Protective Efficacy of Passive Immunization with Monoclonal Antibodies in Animal Models of H5N1 Highly Pathogenic Avian Influenza Virus Infection

Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype often cause severe pneumonia and multiple organ failure in humans, with reported case fatality rates of more than 60%. To develop a clinical antibody therapy, we generated a human-mouse chimeric monoclonal antibody (MAb) ch61 that...

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Autors principals: Itoh, Yasushi, Yoshida, Reiko, Shichinohe, Shintaro, Higuchi, Megumi, Ishigaki, Hirohito, Nakayama, Misako, Pham, Van Loi, Ishida, Hideaki, Kitano, Mitsutaka, Arikata, Masahiko, Kitagawa, Naoko, Mitsuishi, Yachiyo, Ogasawara, Kazumasa, Tsuchiya, Hideaki, Hiono, Takahiro, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi, Ito, Mutsumi, Quynh Mai, Le, Kawaoka, Yoshihiro, Miyamoto, Hiroko, Ishijima, Mari, Igarashi, Manabu, Suzuki, Yasuhiko, Takada, Ayato
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055766/
https://ncbi.nlm.nih.gov/pubmed/24945244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004192
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