Protective Efficacy of Passive Immunization with Monoclonal Antibodies in Animal Models of H5N1 Highly Pathogenic Avian Influenza Virus Infection

Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype often cause severe pneumonia and multiple organ failure in humans, with reported case fatality rates of more than 60%. To develop a clinical antibody therapy, we generated a human-mouse chimeric monoclonal antibody (MAb) ch61 that...

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Hlavní autoři: Itoh, Yasushi, Yoshida, Reiko, Shichinohe, Shintaro, Higuchi, Megumi, Ishigaki, Hirohito, Nakayama, Misako, Pham, Van Loi, Ishida, Hideaki, Kitano, Mitsutaka, Arikata, Masahiko, Kitagawa, Naoko, Mitsuishi, Yachiyo, Ogasawara, Kazumasa, Tsuchiya, Hideaki, Hiono, Takahiro, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi, Ito, Mutsumi, Quynh Mai, Le, Kawaoka, Yoshihiro, Miyamoto, Hiroko, Ishijima, Mari, Igarashi, Manabu, Suzuki, Yasuhiko, Takada, Ayato
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055766/
https://ncbi.nlm.nih.gov/pubmed/24945244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004192
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