Tumor-Derived Interleukin-1 Promotes Lymphangiogenesis and Lymph Node Metastasis through M2-Type Macrophages

Tumors formed by a highly metastatic human lung cancer cell line are characterized by activated signaling via vascular endothelial growth factor (VEGF)-C through its receptor (VEGFR-3) and aggressive lymph node metastasis. In this study, we examined how these highly metastatic cancers acquired aggre...

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Détails bibliographiques
Auteurs principaux: Watari, Kosuke, Shibata, Tomohiro, Kawahara, Akihiko, Sata, Ken-ichi, Nabeshima, Hiroshi, Shinoda, Ai, Abe, Hideyuki, Azuma, Koichi, Murakami, Yuichi, Izumi, Hiroto, Takahashi, Takashi, Kage, Masayoshi, Kuwano, Michihiko, Ono, Mayumi
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055709/
https://ncbi.nlm.nih.gov/pubmed/24924428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099568
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