Retinoic Acid Therapy Resistance Progresses from Unilineage to Bilineage in HL-60 Leukemic Blasts

Emergent resistance can be progressive and driven by global signaling aberrations. All-trans retinoic acid (RA) is the standard therapeutic agent for acute promyelocytic leukemia, but 10–20% of patients are not responsive, and initially responsive patients relapse and develop retinoic acid resistanc...

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Bibliographic Details
Main Authors: Jensen, Holly A., Bunaciu, Rodica P., Ibabao, Christopher N., Myers, Rebecca, Varner, Jeffrey D., Yen, Andrew
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055670/
https://ncbi.nlm.nih.gov/pubmed/24922062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098929
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