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Interleukin 2 induces CD8+ T cell-mediated suppression of human immunodeficiency virus replication in CD4+ T cells and this effect overrides its ability to stimulate virus expression.

The nonlytic suppression of human immunodeficiency virus (HIV) production from infected CD4+ T cells by CD8+ lymphocytes from HIV-infected individuals is one of the most potent host-mediated antiviral activities observed in vitro. We demonstrate that the pleiotropic cytokine interleukin 2 (IL-2), bu...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kinter, A L, Bende, S M, Hardy, E C, Jackson, R, Fauci, A S
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40555/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479922/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.10985
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