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Loss of Ubp3 increases silencing, decreases unequal recombination in rDNA, and shortens the replicative life span in Saccharomyces cerevisiae

Ubp3 is a conserved ubiquitin protease that acts as an antisilencing factor in MAT and telomeric regions. Here we show that ubp3∆ mutants also display increased silencing in ribosomal DNA (rDNA). Consistent with this, RNA polymerase II occupancy is lower in cells lacking Ubp3 than in wild-type cells...

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Autors principals: Öling, David, Masoom, Rehan, Kvint, Kristian
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055270/
https://ncbi.nlm.nih.gov/pubmed/24760971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-10-0591
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