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Platelet-activating factor antagonists enhance intracellular degradation of amyloid-β(42) in neurons via regulation of cholesterol ester hydrolases
INTRODUCTION: The progressive dementia that is characteristic of Alzheimer’s disease is associated with the accumulation of amyloid-beta (Aβ) peptides in extracellular plaques and within neurons. Aβ peptides are targeted to cholesterol-rich membrane micro-domains called lipid rafts. Observations tha...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4055000/ https://ncbi.nlm.nih.gov/pubmed/24625058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt245 |
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