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Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids.

The orphan nuclear receptor steroidogenic factor 1 (SF-1) is expressed in the adrenal cortex and gonads and regulates the expression of several P450 steroid hydroxylases in vitro. We examined the role of SF-1 in the adrenal glands and gonads in vivo by a targeted disruption of the mouse SF-1 gene. A...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Sadovsky, Y, Crawford, P A, Woodson, K G, Polish, J A, Clements, M A, Tourtellotte, L M, Simburger, K, Milbrandt, J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40546/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479914/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.10939
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