Type I Interferon Signals in Macrophages and Dendritic Cells Control Dengue Virus Infection: Implications for a New Mouse Model To Test Dengue Vaccines

Dengue virus (DENV) infects an estimated 400 million people every year, causing prolonged morbidity and sometimes mortality. Development of an effective vaccine has been hampered by the lack of appropriate small animal models; mice are naturally not susceptible to DENV and only become infected if hi...

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Autors principals: Züst, Roland, Toh, Ying-Xiu, Valdés, Iris, Cerny, Daniela, Heinrich, Julia, Hermida, Lisset, Marcos, Ernesto, Guillén, Gerardo, Kalinke, Ulrich, Shi, Pei-Yong, Fink, Katja
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054447/
https://ncbi.nlm.nih.gov/pubmed/24741106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03827-13
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