Type I Interferon Signals in Macrophages and Dendritic Cells Control Dengue Virus Infection: Implications for a New Mouse Model To Test Dengue Vaccines

Dengue virus (DENV) infects an estimated 400 million people every year, causing prolonged morbidity and sometimes mortality. Development of an effective vaccine has been hampered by the lack of appropriate small animal models; mice are naturally not susceptible to DENV and only become infected if hi...

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Detalhes bibliográficos
Main Authors: Züst, Roland, Toh, Ying-Xiu, Valdés, Iris, Cerny, Daniela, Heinrich, Julia, Hermida, Lisset, Marcos, Ernesto, Guillén, Gerardo, Kalinke, Ulrich, Shi, Pei-Yong, Fink, Katja
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054447/
https://ncbi.nlm.nih.gov/pubmed/24741106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03827-13
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