Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses

Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses. As L domains are important for budding and are highly conserved...

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Bibliografiske detaljer
Main Authors: Han, Ziying, Lu, Jianhong, Liu, Yuliang, Davis, Benjamin, Lee, Michael S., Olson, Mark A., Ruthel, Gordon, Freedman, Bruce D., Schnell, Matthias J., Wrobel, Jay E., Reitz, Allen B., Harty, Ronald N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054416/
https://ncbi.nlm.nih.gov/pubmed/24741084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00591-14
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