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Neurofibromatosis Type 1 Alternative Splicing Is a Key Regulator of Ras Signaling in Neurons
Neurofibromatosis type I (Nf1) is a GTPase-activating protein (GAP) that inactivates the oncoprotein Ras and plays important roles in nervous system development and learning. Alternative exon 23a falls within the Nf1 GAP domain coding sequence and is tightly regulated in favor of skipping in neurons...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4054297/ https://ncbi.nlm.nih.gov/pubmed/24710274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00019-14 |
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