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RASSF1A Inactivation Unleashes a Tumor Suppressor/Oncogene Cascade with Context-Dependent Consequences on Cell Cycle Progression

The RASSF1A gene is one of the most frequently inactivated genes in over 30 different types of cancers (H. Donninger, M. D. Vos, and G. J. Clark, J. Cell Sci. 120:3163–3172, 2007, http://dx.doi.org/10.1242/jcs.010389). Despite the prevalence of RASSF1A silencing in human cancer, the mechanism by whi...

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Autori principali: Ram, Rosalyn R., Mendiratta, Saurabh, Bodemann, Brian O., Torres, Michael J., Eskiocak, Ugur, White, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054282/
https://ncbi.nlm.nih.gov/pubmed/24732797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01506-13
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