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Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines
We demonstrate a method for the prediction of chemotherapeutic response in patients using only before-treatment baseline tumor gene expression data. First, we fitted models for whole-genome gene expression against drug sensitivity in a large panel of cell lines, using a method that allows every gene...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4054092/ https://ncbi.nlm.nih.gov/pubmed/24580837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2014-15-3-r47 |
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