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Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines

We demonstrate a method for the prediction of chemotherapeutic response in patients using only before-treatment baseline tumor gene expression data. First, we fitted models for whole-genome gene expression against drug sensitivity in a large panel of cell lines, using a method that allows every gene...

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Detalhes bibliográficos
Main Authors: Geeleher, Paul, Cox, Nancy J, Huang, R Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054092/
https://ncbi.nlm.nih.gov/pubmed/24580837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2014-15-3-r47
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