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Characterizing and measuring bias in sequence data

BACKGROUND: DNA sequencing technologies deviate from the ideal uniform distribution of reads. These biases impair scientific and medical applications. Accordingly, we have developed computational methods for discovering, describing and measuring bias. RESULTS: We applied these methods to the Illumin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ross, Michael G, Russ, Carsten, Costello, Maura, Hollinger, Andrew, Lennon, Niall J, Hegarty, Ryan, Nusbaum, Chad, Jaffe, David B
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053816/
https://ncbi.nlm.nih.gov/pubmed/23718773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-5-r51
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