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Accounting for cellular heterogeneity is critical in epigenome-wide association studies

BACKGROUND: Epigenome-wide association studies of human disease and other quantitative traits are becoming increasingly common. A series of papers reporting age-related changes in DNA methylation profiles in peripheral blood have already been published. However, blood is a heterogeneous collection o...

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Hlavní autoři: Jaffe, Andrew E, Irizarry, Rafael A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053810/
https://ncbi.nlm.nih.gov/pubmed/24495553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2014-15-2-r31
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