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Advancing the functional utility of PAR-CLIP by quantifying background binding to mRNAs and lncRNAs

BACKGROUND: Sequence specific RNA binding proteins are important regulators of gene expression. Several related crosslinking-based, high-throughput sequencing methods, including PAR-CLIP, have recently been developed to determine direct binding sites of global protein-RNA interactions. However, no s...

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Autori principali: Friedersdorf, Matthew B, Keene, Jack D
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053780/
https://ncbi.nlm.nih.gov/pubmed/24393468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2014-15-1-r2
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