voom: precision weights unlock linear model analysis tools for RNA-seq read counts

New normal linear modeling strategies are presented for analyzing read counts from RNA-seq experiments. The voom method estimates the mean-variance relationship of the log-counts, generates a precision weight for each observation and enters these into the limma empirical Bayes analysis pipeline. Thi...

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Detalhes bibliográficos
Main Authors: Law, Charity W, Chen, Yunshun, Shi, Wei, Smyth, Gordon K
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053721/
https://ncbi.nlm.nih.gov/pubmed/24485249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2014-15-2-r29
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