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voom: precision weights unlock linear model analysis tools for RNA-seq read counts
New normal linear modeling strategies are presented for analyzing read counts from RNA-seq experiments. The voom method estimates the mean-variance relationship of the log-counts, generates a precision weight for each observation and enters these into the limma empirical Bayes analysis pipeline. Thi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4053721/ https://ncbi.nlm.nih.gov/pubmed/24485249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2014-15-2-r29 |
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