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Contributions of Edema Factor and Protective Antigen to the Induction of Protective Immunity by Bacillus anthracis Edema Toxin as an Intranasal Adjuvant
We have shown that intranasal coapplication of Bacillus anthracis protective Ag (PA) together with a B. anthracis edema factor (EF) mutant having reduced adenylate cyclase activity (i.e., EF-S414N) enhances anti-PAAb responses, but also acts as a mucosal adjuvant for coadministered unrelated Ags. To...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4053574/ https://ncbi.nlm.nih.gov/pubmed/20952678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902795 |
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