Contributions of Edema Factor and Protective Antigen to the Induction of Protective Immunity by Bacillus anthracis Edema Toxin as an Intranasal Adjuvant

We have shown that intranasal coapplication of Bacillus anthracis protective Ag (PA) together with a B. anthracis edema factor (EF) mutant having reduced adenylate cyclase activity (i.e., EF-S414N) enhances anti-PAAb responses, but also acts as a mucosal adjuvant for coadministered unrelated Ags. To...

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Detalhes bibliográficos
Main Authors: Duverger, Alexandra, Carré, Jeanne-Marie, Jee, Junbae, Leppla, Stephen H., Cormet-Boyaka, Estelle, Tang, Wei-Jen, Tomé, Daniel, Boyaka, Prosper N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053574/
https://ncbi.nlm.nih.gov/pubmed/20952678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902795
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