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Prenatal stress decreases Bdnf expression and increases methylation of Bdnf exon IV in rats

There is ample evidence that exposure to stress during gestation increases the risk of the offspring to develop mood disorders. Brain-derived neurotrophic factor (Bdnf) plays a critical role during neuronal development and is therefore a prime candidate to modulate neuronal signaling in adult offspr...

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Detalhes bibliográficos
Main Authors: Boersma, Gretha J, Lee, Richard S, Cordner, Zachary A, Ewald, Erin R, Purcell, Ryan H, Moghadam, Alexander A, Tamashiro, Kellie L
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053462/
https://ncbi.nlm.nih.gov/pubmed/24365909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.27558
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