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Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity

Morphine and structurally related derivatives are highly effective analgesics, and the mainstay in the medical management of moderate to severe pain. Pharmacological actions of opioid analgesics are primarily mediated through agonism at the µ opioid peptide (MOP) receptor, a G protein-coupled recept...

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書誌詳細
主要な著者: Ben Haddou, Tanila, Béni, Szabolcs, Hosztafi, Sándor, Malfacini, Davide, Calo, Girolamo, Schmidhammer, Helmut, Spetea, Mariana
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053365/
https://ncbi.nlm.nih.gov/pubmed/24919067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099231
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