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Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity

Morphine and structurally related derivatives are highly effective analgesics, and the mainstay in the medical management of moderate to severe pain. Pharmacological actions of opioid analgesics are primarily mediated through agonism at the µ opioid peptide (MOP) receptor, a G protein-coupled recept...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ben Haddou, Tanila, Béni, Szabolcs, Hosztafi, Sándor, Malfacini, Davide, Calo, Girolamo, Schmidhammer, Helmut, Spetea, Mariana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053365/
https://ncbi.nlm.nih.gov/pubmed/24919067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099231
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