Global transcriptional and translational repression in human embryonic stem cells-derived Rett Syndrome neurons

Rett Syndrome (RTT) is caused by mutations of MECP2, a methyl CpG binding protein thought to act as a global transcriptional repressor. Here we show, using an isogenic human embryonic stem cell model of RTT, that MECP2 mutant neurons display key molecular and cellular features of this disorder. Unbi...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Li, Yun, Wang, Haoyi, Muffat, Julien, Cheng, Albert W., Orlando, David A., Lovén, Jakob, Kwok, Show-ming, Feldman, Danielle A., Bateup, Helen S., Gao, Qing, Hockemeyer, Dirk, Mitalipova, Maisam, Lewis, Caroline A., Vander Heiden, Matthew G., Sur, Mriganka, Young, Richard A., Jaenisch, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053296/
https://ncbi.nlm.nih.gov/pubmed/24094325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.09.001
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares