Global transcriptional and translational repression in human embryonic stem cells-derived Rett Syndrome neurons

Rett Syndrome (RTT) is caused by mutations of MECP2, a methyl CpG binding protein thought to act as a global transcriptional repressor. Here we show, using an isogenic human embryonic stem cell model of RTT, that MECP2 mutant neurons display key molecular and cellular features of this disorder. Unbi...

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Main Authors: Li, Yun, Wang, Haoyi, Muffat, Julien, Cheng, Albert W., Orlando, David A., Lovén, Jakob, Kwok, Show-ming, Feldman, Danielle A., Bateup, Helen S., Gao, Qing, Hockemeyer, Dirk, Mitalipova, Maisam, Lewis, Caroline A., Vander Heiden, Matthew G., Sur, Mriganka, Young, Richard A., Jaenisch, Rudolf
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053296/
https://ncbi.nlm.nih.gov/pubmed/24094325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.09.001
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