Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening

INTRODUCTION: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to its receptors, TRAIL-receptor 1 (TRAIL-R1) and TRAIL-receptor 2 (TRAIL-R2), leading to apoptosis by activation of caspase-8 and the downstream executioner caspases, caspase-3 and caspase-7 (caspase-3/7). Triple-ne...

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Hauptverfasser: Garimella, Sireesha V, Gehlhaus, Kristie, Dine, Jennifer L, Pitt, Jason J, Grandin, Magdalena, Chakka, Sirisha, Nau, Marion M, Caplen, Natasha J, Lipkowitz, Stanley
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053258/
https://ncbi.nlm.nih.gov/pubmed/24745479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3645
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