The 4-Cysteine Zinc-Finger Motif of the RNA Polymerase Regulator DksA serves as a Thiol Switch for Sensing Oxidative and Nitrosative Stress

We show that thiols in the 4-cysteine zinc-finger motif of DksA, an RNA polymerase accessory protein known to regulate the stringent response, sense oxidative and nitrosative stress. Hydrogen peroxide- or nitric oxide (NO)-mediated modifications of thiols in the DksA 4-cysteine zinc-finger motif rel...

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Main Authors: Henard, Calvin A., Tapscott, Timothy, Crawford, Matthew A., Husain, Maroof, Doulias, Paschalis-Thomas, Porwollik, Steffen, Liu, Lin, McClelland, Michael, Ischiropoulos, Harry, Vázquez-Torres, Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053250/
https://ncbi.nlm.nih.gov/pubmed/24354846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12498
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