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Amino acid copolymers that alleviate experimental autoimmune encephalomyelitis (EAE) in vivo interact with heparan sulfates and gp96 in antigen presenting cells

Multiple Sclerosis (MS) is an autoimmune disease that affects the central nervous system. One approved treatment for relapsing forms of MS is YEAK, a random copolymer of the amino acids Tyr, Glu, Ala and Lys. YFAK, a second-generation copolymer composed of Tyr, Phe, Ala and Lys, is more successful i...

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Bibliografiske detaljer
Main Authors: Koenig, Paul-Albert, Spooner, Eric, Kawamoto, Norio, Strominger, Jack L., Ploegh, Hidde L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053211/
https://ncbi.nlm.nih.gov/pubmed/23740953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300345
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