A Phase 2 Study of Flavopiridol (Alvocidib) in Combination with Docetaxel in Refractory, Metastatic Pancreatic Cancer (NCI#6366)

BACKGROUND/AIMS: Pancreatic adenocarcinoma (PC) harbors frequent alterations of p16, resulting in cell cycle dysregulation. A phase I study of docetaxel and flavopiridol, a pan-cyclin dependent kinase inhibitor, demonstrated encouraging clinical activity in PC. This phase II study was designed to fu...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Carvajal, Richard D., Tse, Archie, Shah, Manish A., Lefkowitz, Robert A., Gonen, Mithat, Gilman-Rosen, Lisa, Kortmansky, Jeremy, Kelsen, David P., Schwartz, Gary K., O'Reilly, Eileen M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053191/
https://ncbi.nlm.nih.gov/pubmed/19451750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000187135
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia