A Phase 2 Study of Flavopiridol (Alvocidib) in Combination with Docetaxel in Refractory, Metastatic Pancreatic Cancer (NCI#6366)

BACKGROUND/AIMS: Pancreatic adenocarcinoma (PC) harbors frequent alterations of p16, resulting in cell cycle dysregulation. A phase I study of docetaxel and flavopiridol, a pan-cyclin dependent kinase inhibitor, demonstrated encouraging clinical activity in PC. This phase II study was designed to fu...

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Detalhes bibliográficos
Main Authors: Carvajal, Richard D., Tse, Archie, Shah, Manish A., Lefkowitz, Robert A., Gonen, Mithat, Gilman-Rosen, Lisa, Kortmansky, Jeremy, Kelsen, David P., Schwartz, Gary K., O'Reilly, Eileen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053191/
https://ncbi.nlm.nih.gov/pubmed/19451750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000187135
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