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Chemosensitivity and p53; new tricks by an old dog

The effect of TP53 mutations on chemosensitivity in breast cancer is a controversial issue. In an elegant paper in Cancer Cell, Jackson and colleagues report wtp53 protein to block anti-tumour effects of doxorubicin treatment in mice. p53 did so by inducing senescence, thereby preventing mitotic cat...

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Библиографические подробности
Главные авторы: Lønning, Per E, Knappskog, Stian
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053121/
https://ncbi.nlm.nih.gov/pubmed/23131146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3326
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