Deletion of Hemojuvelin, an Iron-Regulatory Protein, in Mice Results in Abnormal Angiogenesis and Vasculogenesis in Retina Along With Reactive Gliosis

PURPOSE. Loss-of-function mutations in hemojuvelin (HJV) cause juvenile hemochromatosis, an iron-overload disease. Deletion of Hjv in mice results in excessive iron accumulation and morphologic changes in the retina. Here, we studied the retinal vasculature in Hjv(−/−) mice. METHODS. Age-matched wil...

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Main Authors: Tawfik, Amany, Gnana-Prakasam, Jaya P., Smith, Sylvia B., Ganapathy, Vadivel
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053073/
https://ncbi.nlm.nih.gov/pubmed/24812553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-13677
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