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An RNA Polymerase II-coupled function for histone H3K36 methylation in checkpoint activation and DSB repair

Histone modifications are major determinants of DNA double-strand break (DSB) response and repair. Here we elucidate a DSB repair function for transcription-coupled Set2 methylation at H3 lysine 36 (H3K36me). Cells devoid of Set2/H3K36me are hypersensitive to DNA-damaging agents and site-specific DS...

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Bibliografiske detaljer
Main Authors: Jha, Deepak Kumar, Strahl, Brian D.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052371/
https://ncbi.nlm.nih.gov/pubmed/24910128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4965
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