Conformational Switching in PolyGln Amyloid Fibrils Resulting from a Single Amino Acid Insertion

The established correlation between neurodegenerative disorders and intracerebral deposition of polyglutamine aggregates motivates attempts to better understand their fibrillar structure. We designed polyglutamines with a few lysines inserted to overcome the hindrance of extreme insolubility and two...

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Detaylı Bibliyografya
Asıl Yazarlar: Huang, Rick K., Baxa, Ulrich, Aldrian, Gudrun, Ahmed, Abdullah B., Wall, Joseph S., Mizuno, Naoko, Antzutkin, Oleg, Steven, Alasdair C., Kajava, Andrey V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Biophysical Society 2014
Konular:
Membranes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052364/
https://ncbi.nlm.nih.gov/pubmed/24853742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.03.047
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