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Conformational Switching in PolyGln Amyloid Fibrils Resulting from a Single Amino Acid Insertion
The established correlation between neurodegenerative disorders and intracerebral deposition of polyglutamine aggregates motivates attempts to better understand their fibrillar structure. We designed polyglutamines with a few lysines inserted to overcome the hindrance of extreme insolubility and two...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Biophysical Society
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4052364/ https://ncbi.nlm.nih.gov/pubmed/24853742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.03.047 |
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