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The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells

AIMS/HYPOTHESIS: We used the db/db mouse to determine the nature of the secretory defect in intact islets. METHODS: Glucose tolerance was compared in db/db and wild-type (WT) mice. Isolated islets were used: to measure insulin secretion and calcium in a two-photon assay of single-insulin-granule fus...

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Detalhes bibliográficos
Main Authors: Do, Oanh H., Low, Jiun T., Gaisano, Herbert Y., Thorn, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052007/
https://ncbi.nlm.nih.gov/pubmed/24705605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-014-3226-8
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