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The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells
AIMS/HYPOTHESIS: We used the db/db mouse to determine the nature of the secretory defect in intact islets. METHODS: Glucose tolerance was compared in db/db and wild-type (WT) mice. Isolated islets were used: to measure insulin secretion and calcium in a two-photon assay of single-insulin-granule fus...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer Berlin Heidelberg
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4052007/ https://ncbi.nlm.nih.gov/pubmed/24705605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-014-3226-8 |
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