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Profilin 1 Associates with Stress Granules and ALS-Linked Mutations Alter Stress Granule Dynamics
Mutations in the PFN1 gene encoding profilin 1 are a rare cause of familial amyotrophic lateral sclerosis (ALS). Profilin 1 is a well studied actin-binding protein but how PFN1 mutations cause ALS is unknown. The budding yeast, Saccharomyces cerevisiae, has one PFN1 ortholog. We expressed the ALS-li...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Society for Neuroscience
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4051967/ https://ncbi.nlm.nih.gov/pubmed/24920614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0543-14.2014 |
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