A point mutation in the [2Fe–2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties

NAF-1 is an important [2Fe–2S] NEET protein associated with human health and disease. A mis-splicing mutation in NAF-1 results in Wolfram Syndrome type 2, a lethal childhood disease. Upregulation of NAF-1 is found in epithelial breast cancer cells, and suppression of NAF-1 expression by knockdown si...

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Hlavní autoři: Tamir, Sagi, Eisenberg-Domovich, Yael, Conlan, Andrea R., Stofleth, Jason T., Lipper, Colin H., Paddock, Mark L., Mittler, Ron, Jennings, Patricia A., Livnah, Oded, Nechushtai, Rachel
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2014
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051502/
https://ncbi.nlm.nih.gov/pubmed/24914968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714005458
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