Tanshinone IIA promotes non-amyloidogenic processing of amyloid precursor protein in platelets via estrogen receptor signaling to phosphatidylinositol 3-kinase/Akt

Amyloid β peptide (Aβ) is a proteolytic product of amyloid precursor protein (APP). Recent findings suggested that platelet-derived Aβ is closely associated with the pathogenesis of atherosclerosis (AS). Tanshinone IIA (Tan IIA), a pharmacologically active component of the Chinese herb Salvia miltio...

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Hlavní autoři: SHI, CHUN, ZHU, XIAOMING, WANG, JISHENG, LONG, DAHONG
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2014
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051464/
https://ncbi.nlm.nih.gov/pubmed/24944795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/br.2014.263
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