Pin1-mediated Runx2 modification is critical for skeletal development

Runx2 is the master transcription factor for bone formation. Haploinsufficiency of RUNX2 is the genetic cause of cleidocranial dysplasia (CCD) that is characterized by hypoplastic clavicles and open fontanels. In this study, we found that Pin1, peptidyl prolyl cis-trans isomerase, is a critical regu...

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Main Authors: Yoon, Won-Joon, Islam, Rabia, Cho, Young-Dan, Woo, Kyung-Mi, Baek, Jeong-Hwa, Uchida, Takafumi, Komori, Toshihisa, van Wijnen, Andre, Stein, Janet L., Lian, Jane B., Stein, Gary S., Choi, Je-Yong, Bae, Suk-Chul, Ryoo, Hyun-Mo
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051422/
https://ncbi.nlm.nih.gov/pubmed/23702614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24403
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