Pin1-mediated Runx2 modification is critical for skeletal development

Runx2 is the master transcription factor for bone formation. Haploinsufficiency of RUNX2 is the genetic cause of cleidocranial dysplasia (CCD) that is characterized by hypoplastic clavicles and open fontanels. In this study, we found that Pin1, peptidyl prolyl cis-trans isomerase, is a critical regu...

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Bibliographische Detailangaben
Hauptverfasser: Yoon, Won-Joon, Islam, Rabia, Cho, Young-Dan, Woo, Kyung-Mi, Baek, Jeong-Hwa, Uchida, Takafumi, Komori, Toshihisa, van Wijnen, Andre, Stein, Janet L., Lian, Jane B., Stein, Gary S., Choi, Je-Yong, Bae, Suk-Chul, Ryoo, Hyun-Mo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051422/
https://ncbi.nlm.nih.gov/pubmed/23702614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24403
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