Prolyl Isomerase Pin1-mediated Conformational Change and Subnuclear Focal Accumulation of Runx2 Are Crucial for Fibroblast Growth Factor 2 (FGF2)-induced Osteoblast Differentiation

Fibroblast growth factor 2 (FGF2) signaling plays a pivotal role in bone growth/differentiation through the activation of osteogenic master transcription factor Runx2, which is mediated by the ERK/MAPK-dependent phosphorylation and the p300-dependent acetylation of Runx2. In this study, we found tha...

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Autores principales: Yoon, Won-Joon, Cho, Young-Dan, Kim, Woo-Jin, Bae, Han-Sol, Islam, Rabia, Woo, Kyung-Mi, Baek, Jeong-Hwa, Bae, Suk-Chul, Ryoo, Hyun-Mo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979377/
https://ncbi.nlm.nih.gov/pubmed/24509851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.516237
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