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The Challenge of Targeting Notch in Hematologic Malignancies
Notch signaling can play oncogenic and tumor suppressor roles depending on cell type. Hematologic malignancies encompass a wide range of transformed cells, and consequently the roles of Notch are diverse in these diseases. For example Notch is a potent T-cell oncogene, with >50% of T-cell acute l...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4051192/ https://ncbi.nlm.nih.gov/pubmed/24959528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fped.2014.00054 |
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