Rab18 and a Rab18 GEF complex are required for normal ER structure

The ancestral Rab GTPase Rab18 and both subunits of the Rab3GAP complex are mutated in the human neurological and developmental disorder Warburg Micro syndrome. Here, we demonstrate that the Rab3GAP complex is a specific Rab18 guanine nucleotide exchange factor (GEF). The Rab3GAP complex localizes t...

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Bibliographic Details
Main Authors: Gerondopoulos, Andreas, Bastos, Ricardo Nunes, Yoshimura, Shin-ichiro, Anderson, Rachel, Carpanini, Sarah, Aligianis, Irene, Handley, Mark T., Barr, Francis A.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2014
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050724/
https://ncbi.nlm.nih.gov/pubmed/24891604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201403026
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