C11orf95-RELA fusions drive oncogenic NF-κB signaling in ependymoma

The nuclear factor-κB (NF-κB) family of transcriptional regulators are central mediators of the cellular inflammatory response. Although constitutive NF-κB signaling is present in most human tumours, mutations in pathway members are rare, complicating efforts to understand and block aberrant NF-κB a...

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Autors principals: Parker, Matthew, Mohankumar, Kumarasamypet M., Punchihewa, Chandanamali, Weinlich, Ricardo, Dalton, James D., Li, Yongjin, Lee, Ryan, Tatevossian, Ruth G., Phoenix, Timothy N., Thiruvenkatam, Radhika, White, Elsie, Tang, Bo, Orisme, Wilda, Gupta, Kirti, Rusch, Michael, Chen, Xiang, Li, Yuxin, Nagahawhatte, Panduka, Hedlund, Erin, Finkelstein, David, Wu, Gang, Shurtleff, Sheila, Easton, John, Boggs, Kristy, Yergeau, Donald, Vadodaria, Bhavin, Mulder, Heather L, Becksford, Jared, Gupta, Pankaj, Huether, Robert, Ma, Jing, Song, Guangchun, Gajjar, Amar, Merchant, Thomas, Boop, Frederick, Smith, Amy A, Ding, Li, Lu, Charles, Ochoa, Kerri, Zhao, David, Fulton, Robert S, Fulton, Lucinda L, Mardis, Elaine R., Wilson, Richard K., Downing, James R., Green, Douglas R., Zhang, Jinghui, Ellison, David W., Gilbertson, Richard J.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050669/
https://ncbi.nlm.nih.gov/pubmed/24553141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13109
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